What is the natural cannabinoid CB9?
Scientists have already discovered more than 150 cannabinoids in the cannabis plant, including CB9. The therapeutic potential looks promising in areas such as stress and anxiety management, relaxation and pain and inflammation relief. Want to know what CB9 is, how it's made and what makes it special? We'll answer these questions in this article, which also compares the cannabinoids CB9, CBD, CBG, CBN, and H4CBD.
- What is CB9? Formation and chemical structure
- What are the unprecedented features of CB9?
- Potential benefits of CB9
- Table comparing CB9, CBD, CBG, CBN and H4CBD
- Complex detection
- Conclusion
What is CB9? Formation and chemical structure
The cannabinoid CB9 is found in the cannabis plant and is derived from cannabidiol (CBD). At first glance, it resembles the more famous CBD, given its chemical structure and natural 5-carbon tail. However, there is a subtle difference in the structure that causes it to have psychoactive properties. This makes it fundamentally different from CBD, which has no psychoactive effect.
The process of CB9 formation is still under investigation. It appears that CB9 is produced by a complex chemical reaction that takes place in cannabis. Other cannabinoids, such as CBD and THC, act as starting substances (precursors).
What are the unprecedented features of CB9?
When it comes to the physical properties of CB9, there is another interesting fact. It is reported to have no tendency to crystallise, unlike some other cannabinoids. It is likely that this property will be reflected in how it is processed and stored and will affect its composition in products, stability, solubility and use.
Although similar in structure to CBD and H4CBD compounds, we know that its significant difference is the psychoactive properties just mentioned.
Comparing the effects with other cannabinoids, CB9 has mild psychoactive effects similar to HHC (hexahydrocannabinol) and delta-8-THC.
Potential benefits of CB9
Scientists have discovered that most of the effects of cannabinoids depend on how they interact with the endocannabinoid system (ECS) in the body. The role of the ECS is to maintain balance - homeostasis. This complex, intricate network is responsible for various activities of the body, such as pain perception, sleep, mood, immunity, appetite and movement coordination. The ECS consists of endocannabinoid receptors (most famously CB1 and CB2), endocannabinoids and enzymes.
CB1 receptors are found in the central nervous system (in the brain), while CB2 receptors spread throughout the immune system, digestive tract and other organs.
CBD has no psychoactive effect because it does not bind to CB1 and CB2 receptors. Rather, it modulates their activity and also affects serotonin, adenosine and vanilloid receptors.
How CB9 interacts with the ECS is currently unclear, but its interaction with the ECS is likely to be different.
CB9 is likely to induce euphoria, relaxation and slightly altered sensory perception.
Research into this cannabinoid is just beginning. It is expected that CB9 could have similar properties to other cannabinoids, especially neuroprotective, anti-inflammatory and sedative properties. It could be particularly beneficial in:
- chronic pain and inflammation
- promoting overall well-being (relieving stress and anxiety)
- difficulty sleeping
- neurodegenerative disease
Table comparing CB9, CBD, CBG, CBN and H4CBD
|
CB9 |
CBD (cannabidiol) |
CBN (cannabinol) |
H4CBD (hexahydro- cannabidiol) |
||
|
Occurrence in cannabis |
Yes |
Yes, the second most abundant cannabinoid in the plant. |
Yes, it is the first cannabinoid that the plant produces at the germination stage. |
Yes, a minor cannabinoid, it is only found in minute amounts in the plant. |
No |
|
Production |
The CBD derivative is produced by a laborious chemical process in the cannabis plant, with other cannabinoids such as THC and CBD serving as starting substances. |
Extraction from cannabis is carried out using extraction methods:
|
Precursor for the synthesis of CBD, THC and other cannabinoids.
Adult plants contain only 1 % CBG, young plants about 5 % CBG. |
It is produced when THC is decomposed (by heat, light and oxygen) and is, in simple terms, an oxidised version of THC. |
CBD derivative, produced by a process called hydrogenation, 4 hydrogen atoms are added to the CBD molecule. |
|
Psychoactive properties |
Yes |
No |
No |
Currently considered non-psychoactive. |
Available |
|
Interaction with receptors in (ECS) |
Probably different interaction with the ECS of the human body. The interaction between CB9 and ECS is still under investigation. |
Low affinity, acts as a modulator of CB1 and CB2 receptors. It also acts on adenosine, serotonin and vanilloid receptors. |
It integrates by partial activation of CB1 and CB2 receptors and also affects the 5HT1A-receptor. |
Binding to CB1 and CB2 receptors, probably higher affinity for CB2 receptors. |
Molecule 9R H4CBD: probably binds very efficiently to CB1 receptors. |
|
Effects |
Milder effects than delta-9, similar to those of HHC and delta-8-THC. |
It is not psychoactive. |
It is not psychoactive. |
Possible, potentially mildly psychoactive effects. |
The effects are similar to CBD, but with the difference that it binds better to CB1 receptors. |
|
Possible benefits |
|
|
|
|
|
|
Product offer |
Limited supply at the moment.
|
The most affordable cannabinoid on the market.
|
CBG oils and drops
|
|
|
|
Legality |
Legal in the Czech Republic, legal status not determined. |
Legal |
Legal |
Legal |
Legal |
Complex detection
Identifying CB9 in the cannabis plant is difficult, which poses an interesting challenge for scientific research. Tests do not pick it up well because of the chemical difference. Standard HPLC (high performance liquid chromatography) analytical methods may not be reliable enough.
From a practical point of view, complex detection poses a challenge not only for manufacturers but also for regulators.
Conclusion
CB9 is a new cannabinoid found in the cannabis plant and is a derivative of CBD. Its psychoactive properties are related to the difference it has in its molecular structure. Currently, scientists are trying to find out how CB9 interacts with the endocannabinoid system with our body and how it affects it.
Of course, to get to the very heart of the potential benefits, we need clinical trials to evaluate its efficacy, safety and method of use.
Author Patricie Mikolášová, translation by AI
Photo: Shutterstock
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