The rare and mysterious cannabinoid CBE: What do we know about it so far?
When we hear the word cannabinoids, most of us think of CBD, CBG, CBN, or THC. However, cannabis contains more than 150 different cannabinoids, some of which are still waiting to be discovered. Today, we will take a look at the rare cannabinoid CBE – how it is produced, what potential effects it has, and how it differs from CBD. Discover everything we know so far about this mysterious compound.
- What is CBE and how is it produced?
- Cannabinoid CBE: What are its effects?
- How does CBE differ from CBD?
- What CBE products are available on the market?
- Conclusion
What is CBE and how is it formed?
CBE, or cannabielsoin, is a metabolite of CBD (cannabidiol).
A metabolite is a substance formed during metabolism, which is a set of chemical reactions in living organisms that ensure the conversion and processing of substances. It is formed by the breakdown or conversion of larger molecules into smaller ones and plays an important role in energy metabolism, detoxification, and other biological processes.
The cannabinoid CBE was discovered as early as in 1973, when scientists conducted experiments with cannabis extracts in an oxygen-free environment. It was not until 18 years later, in 1991, that it was confirmed that CBE is formed as a metabolite of CBD. This conversion takes place primarily in the liver, where enzymes convert CBD into CBE.
CBE is therefore not naturally found in the cannabis plant itself, but is only produced when CBD is metabolized in the body or when CBD is converted in a laboratory using specific chemical processes.
The cannabinoid CBE: What are its effects?
Like other cannabinoids, CBE acts on the endocannabinoid system (ECS), which influences a number of essential processes such as mood, sleep, immunity, and pain perception. The exact mechanism of action of CBE is not yet fully understood, but initial studies have shown that CBE binds to and activates the CB1 receptor, but in a different way than THC, which could indicate specific therapeutic potential.
What we know so far about the effects of CBE:
- No psychoactive effects – does not cause a "high" like THC
- Potential therapeutic properties similar to CBD: CBE is thought to have relaxation, anti-inflammatory, neuroprotective, and antioxidant effects.
Research on CBE is still in its early stages, and more studies are needed to confirm its benefits.
How is CBE different from CBD?
Although CBE and CBD are chemically similar, there is one difference between them – CBE contains one more oxygen atom than CBD.
- Molecular formula of CBE: C21H30O3 (21 carbon atoms, 30 hydrogen atoms, and 3 oxygen atoms)
- CBD molecular formula: C21H30O2 (21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms)
This slight change is the result of CBD oxidation and may affect how CBE works in the body.
Another difference is the amount of research and studies conducted – CBD has been studied for a long time, and we know how it works inside the body and what side effects it has, while CBE remains in the background, with only a handful of scientific findings available. For this reason, it is not yet possible to accurately compare the effects of CBE with those of CBD.
What CBE products are available on the market?
In order to produce CBE products, CBD must be CBD deliberately oxidized or exposed to simulated digestive enzymes that mimic its natural breakdown in the liver.
CBE is still rare, so the availability of CBE products is currently very limited. Products such as isolates, tinctures, oils, and capsules are expected to appear on the market in the near future.
Conclusion
CBE (cannabielsoin) is a metabolite of CBD that is produced when CBD is broken down in the body or in a laboratory. It does not occur naturally in cannabis but can be produced from CBD through controlled oxidation.
Its effects have not yet been fully explored, but it may have similar properties to CBD – it is not psychoactive.
Products containing CBE are still rare, but with growing interest and ongoing research, they should become more widely available in the future and may find their place among popular cannabis compounds.
Author: Patricie Mikolášová
Foto: AI
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